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The bulk of regulation of organic chemicals in many countries is carried out by government agencies such as the United States Environmental Protection Agency (US EPA), the European Union, and the Japanese Ministry of the Environment and the Ministry of Health, Labour and Welfare. Increasingly, non-governmental organizations concerned about health and environmental concerns are also taking part in the regulation of certain types of organic chemicals. Many countries recognize that it is not feasible or desirable for each country to develop its own organic chemical control program, and have therefore adopted international guidance documents that provide some commonality to many countries. Such internationally recognized standards are available through the Health and Safety Executive, the American Conference of Governmental Industrial Hygienists (ACGIH) and the American Academy of Toxicology (AAT).
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The European Union has brought in legislation known as the Registration, Evaluation, Authorization and Restriction of Chemicals (REACH) which sets out a framework for the legal registration, authorization and restriction of chemicals, in order to protect human health and the environment from harm.
While for some compounds, hazard identification and risk assessment have taken place before the application of the REACH legislation, many organisations such as the World Health Organization, the United Nations Environment Programme, the International Organization for Standardization (ISO), the European Commission and the EU Member States have now commenced the process of completing the implementation of this new European legislation. The highly toxic organic chemicals such as ethylene oxide, bisphenol A, and trichloroethylene have been identified by the REACH legislation as being the most toxic substances which need to be prioritized for evaluation and control. However, the process is being phased in so that many existing chemicals will not be evaluated until the later phases and most countries are developing their own unique mechanisms for regulation.